TRT can lead to fluid retention, causing mild swelling in the hands, feet, or ankles. While this isn’t a direct effect of testosterone itself, certain indirect mechanisms might affect how the body retains sodium and water.
If you’re starting TRT, you might notice this side effect during the early stages, but it often resolves as your body adjusts. High doses of TRT are more likely to cause water retention, but it is often mild and may subside once the body adjusts to therapy.
However, for men with heart, liver, or kidney conditions, extra care and caution are needed, as fluid retention in these cases can lead to serious complications. Adjusting your dosage and keeping an eye on your diet can help manage this side effect.